What should we do first if we see these signs?

Disconnect the affected hosts from the network, keep their logs, reset the credentials used on them and call your incident-response provider. If your organisation is in scope of NIS2NIS2: the EU's second Network and Information Security directive. The EU cybersecurity law (Directive (EU) 2022/2555) that sets security and incident-reporting duties for many companies., the 24-hour early warning starts when you become aware of a significant incident.

This answer also appears, with more context, here: Detect ransomware on the network

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Terms used here

NIS2 (the EU's second Network and Information Security directive)
The EU cybersecurity law (Directive (EU) 2022/2555) that sets security and incident-reporting duties for many companies.

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